Jose Ramirez hit a two-run homer with two outs in the ninth inning Wednesday night, giving Cleveland a 5-3 win over the Chicago White Sox that snapped an Indians' losing streak that felt like more than three games.

Francisco Lindor singled with one out against Jace Fry (1-1) before Jason Kipnis struck out. Chicago manager Rick Renteria brought in right-hander Kelvin Herrera to face the switch-hitting Ramirez and Lindor stole second on a 2-1 pitch.

Ramirez crushed Herrera's next pitch - a 96 mph fastball - through a stiff wind blowing straight into home plate that knocked down at least six previous flies and kept them in the ballpark.

Brad Hand (2-1) pitched a perfect ninth for the win as the Indians improved to just 5-9 in the AL Central.

Shane Bieber allowed the White Sox just one run in 19 innings over three starts, gave up two singles and a sacrifice in the seventh before No. 9 hitter Ryan Cordell hit a game-tying, two-run single.

The Indians finally generated some offense in the fourth, scoring three runs off Lopez, who entered with a 14.14 ERA in two previous starts at Progressive Field.