Moe Wagner scored a career-high 26 points and spurred a furious second-half rally to send Michigan past second-seeded Louisville 73-69 on Sunday and into the Sweet 16.
The seventh-seeded Wolverines (26-11) have won seven straight - six since a frightening plane accident before the Big Ten Tournament. They also earned a ticket to the Midwest Regional in Kansas City, Missouri, their first since 2014.
Donovan Mitchell scored 19 points and Deng Adel had 16 points to lead Louisville (25-9), which had made the Sweet 16 in its last four NCAA Tournament appearances.
But Wagner bailed out the Wolverines from a poor game.
Trailing 45-36 with 16:09 to play, the German native scored on a layup to start a 17-6 run that gave Michigan its first lead since the opening minutes. And after Wagner's 3-pointer broke a 55-55 tie with 6:39 to go, the Wolverines led the rest of the way.
Sindarius Thornwell had 24 points, Chris Silva scored 13 of his 17 points in the second half and seventh-seeded South Carolina stunned No. 2 seed Duke 88-81 on Sunday night to advance to its first Sweet 16 in the NCAA Tournament's expanded bracket.
The Gamecocks (24-10) trailed by 10 points early in the second half after one of its coldest shooting stretches of the season to start. But behind Thornwell's outside shooting and Silva's dominance underneath, South Carolina rallied to win two NCAA games for the first time in 44 years.