Andrew Luck kept pleading with coach Frank Reich to stick with the ground game Sunday.

Reich gladly granted his wish.

After throwing 164 passes the previous three weeks, Luck watched his runners deliver the hard shots and took advantage of the openings by throwing for four touchdowns in a 37-5 rout over Buffalo.

It seems as though with the Colts getting healthy, the offense is more in sync.

Running back Marlon Mack returned from an injured hamstring last week and the Colts responded with back-to-back season-high rushing totals. Even Buffalo's No. 3 ranked defense couldn't slow down the Colts, who ran for 220 yards - the highest total in Luck's seven seasons.

Indy hadn't topped 200 yards since Dec. 18, 2011 against Tennessee, and Mack had a career-high 126 yards on 19 carries.

Luck, meanwhile, went 17 of 23 with 156 yards, hooked up with receiver T.Y. Hilton for two TD passes, another to Mack and one to Eric Swoope.

As a result, Indy (2-5) snapped a four-game losing streak, pulled off its most lopsided victory since a 37-3 victory over Jacksonville on Sept. 29, 2013 and finally celebrated the franchise's 300th win since moving from Baltimore to Indianapolis in 1984.

Indy was in such command, Luck even made the wise decision to run out of bounds at the Bills 1-yard line in the fourth quarter rather than risk an unnecessary hit by reaching for the goal line.

The only thing that didn't go according to script was Adam Vinatieri breaking Morten Andersen's career scoring record.

Vinatieri scored five points to move within five of becoming the NFL's scoring leader despite missing two extra points in one game for the first time in his career.

But it didn't matter against the Bills' struggling offense. Buffalo (2-5) has lost two straight and three of four despite benching turnover-prone Nathan Peterman and starting 35-year-old Derek Anderson in place of the injured Josh Allen.

Anderson went 20 of 31 with 175 yards, three interceptions and lost a fumble in his first start since December 2016.

Putting offensive coordinator Brian Daboll on the field for the first time this season didn't help either. Buffalo has two touchdowns and 31 points in its last four games.

On Sunday, Luck did all the winning things.

He hooked up with Swoope on a 17-yard pass early in the second quarter and found Mack wide open in the right flat for a 29-yard scoring play - just before taking a hit. Mack's conversion run made it 14-0.

Hilton's 5-yard TD catch extended the lead to 21-0 and Mike Mitchell's 47-yard interception return just before halftime set up Vinatieri for a 36-yard field goal to make it 24-0.

All the Bills could muster in the second half was a 34-yard field goal from Stephen Hauschka and a safety when Ryan Kelly's snap sailed over the head of Luck and rolled through the end zone.