Tom Brady completed 20 of 39 passes for 277 yards, hitting James White for a 20-yard score that was the first touchdown of the running back's career. White added a 6-yard run in the third quarter to give New England (10-0) the lead for good.

LeSean McCoy ran 20 times for 82 yards and a 27-yard touchdown and caught six passes for 41 yards to surpass 100 yards from scrimmage for the fourth straight game.

Tyrod Taylor was 20 for 36 for 233 yards for the Bills (5-5), who snapped a two-game winning streak.