Yoan Moncada had four hits, including a homer, walked twice and scored five runs as the White Sox pounded out 25 hits and routed the Detroit Tigers 17-7.
Moncada is 10 for 19 in his last four games after switching to using Jose Abreu's bats.
Avisail Garcia also homered as part of a big game, setting career highs with five hits and seven RBIs in the ballpark where he started his career.
Jose Abreu added four hits for Chicago, which has won five of six.
Miguel Cabrera, Ian Kinsler, Nicholas Castellanos and Jeimer Canderlario homered for Detroit. The Tigers got six extra-base hits to Chicago's four, but lost their sixth in a row.
James Shields (4-6) won for the first time on the road since May 12, 2016, a span of 18 starts.
Chad Bell (0-3) allowed six runs on nine hits and a walk in 3 1/3 innings.
Tim Anderson, who had three hits, had a two-run single in the fourth that put Chicago ahead 4-2. Garcia hit a three-run homer to cap a four-run sixth that made it 10-2.
The Tigers used eight pitchers, and six of them gave up runs.
The teams continue their four-game series on Friday night, with Detroit's Anibal Sanchez (3-4, 7.43) facing Carson Fulmer (2-1, 6.00).
