Trevor Story and Christian Vazquez each hit a three-run home run and drove in four runs as the Boston Red Sox set season highs in runs and hits in a 16-3 win over the Chicago White Sox on Tuesday night.

Story's homer off Dylan Cease capped a four-run first inning. Vazquez hit a three-run shot off Matt Foster to highlight a six-run sixth. Kike Hernandez hit Cease's first pitch for a homer, and Rafael Devers led off the fourth with a homer off Jose Ruiz as the Red Sox extended their winning streak to six games.

The White Sox fell for the fourth time in seven games.

Designated hitter J.D. Martinez had four of the Red Sox's 19 hits.

Boston's 16 runs were its most since scoring 20 in a win over Tampa Bay on Aug. 11, 2021.

Nick Pivetta (3-4) was staked to a 10-0 lead after 4 1/2 innings and pitched six innings of five-hit ball. Pivetta has allowed five earned runs in his last 28 innings (1.61 ERA).

Story is 11 for his last 31 (.355) with seven homers and 18 RBIs. Story is 5 for 10 lifetime against Cease.

White Sox first baseman Jose Abreu hit his first home run since May 4, a two-run shot off Pivetta in the fourth. Tim Anderson had two hits, including an RBI single in the fifth.

The seven runs allowed by Cease (4-2) were his most since Aug. 29, 2019, when he surrendered eight against the Twins. Cease had his shortest outing since Sept. 11, 2021, when he lasted 2 2/3 innings against the Red Sox. Cease pitched five innings of one-run ball at Boston on May 7.

Rich Hill (1-1, 3.90) will face the White Sox on Wednesday at Guaranteed Rate Field. Hill allowed four runs in two innings of a 12-6 win May 19 over the Mariners. Lucas Giolito (2-1, 2.84) will face the Red Sox on Wednesday. Giolito allowed two runs in five innings of a 6-2 loss May 18 at Kansas City.