Danny Jansen hit a three-run homer in the seventh inning and singled home the winning run in the 11th as the Toronto Blue Jays overcame a four-run deficit to defeat the Chicago Cubs 5-4 on Monday night.

Jansen connected off Erich Uelmen for his 11th homer, then won it with a base hit to left field against Mark Leiter Jr. (2-6) that scored Matt Chapman from second base and ended Toronto's three-game skid.

Chicago blew a lead and lost for the 41st time, more than any other big league team.

Toronto tied it 4-all in the eighth when Cavan Biggio hit a two-out double off Manuel Rodriguez and scored on Chapman's single.

Cubs outfielder Ian Happ lined out to begin the 10th and shortstop Bo Bichette doubled automatic runner Nelson Velazquez off second base. That was one of five outs Chicago ran into on the basepaths, including one at third and another at the plate.

After Chicago intentionally walked Alejandro Kirk to start the bottom of the 10th, third baseman Christopher Morel turned a double play on Bichette's grounder. Kirk was initially ruled safe at second, but the Cubs challenged and umpire Nick Mahrley's call was overturned.

The Cubs put runners at second and third with two outs in the 11th but Yimi Garcia (3-4) struck out P.J. Higgins.

Berrios allowed a season-high 10 hits and four runs in 5 2/3 innings. He slammed his glove onto the dugout bench in frustration after being replaced by left-hander Tim Mayza.

Pinch-hitting for Alfonso Rivas, Higgins greeted Mayza with a two-run double. The hit snapped an 0-for-13 slump and was Higgins' second in his past 35 at-bats.

Making the second appearance of his career, Cubs right-hander Javier Assad allowed four hits, all singles, in five scoreless innings. He walked two and struck out one.

Assad escaped a bases-loaded jam in the first by getting Biggio to fly out.

After back-to-back hits by Nick Madrigal and Willson Contreras put runners at second and third with one out in the fifth, Toronto turned a unique double play to end the threat. Happ struck out on a pitch that got away from Jansen, who threw to first to complete the strikeout. Madrigal broke for home on the throw, but Vladimir Guerrero Jr. threw back to Jansen, who got the tag down just in time.

Marcus Stroman (3-6, 4.10 ERA) faces Blue Jays RHP Kevin Gausman (9-9, 3.15) on Tuesday.