Max Fried (7-1) allowed three runs and six hits in six innings, improving to 5-0 in his last seven starts. He is 5-0 in his career against the Cardinals.

Wainwright (3-11), pitching in his home state of Georgia for the final time against the team that drafted him in 2000, allowed six runs and eight hits in 5 2/3 innings, including four solo home runs The 42-year-old right-hander, nearing the end of his 18th big league season, matched his career high for homers allowed.

He is stuck at 198 wins, losing seven straight starts and dropping to 0-10 in 11 outings since winning at the New York Mets on June 17.

Tommy Edman was 2 for 4 with two RBIs for the Cardinals (61-79), who with three more losses would assure their first losing season since 2007.

Cardinals rookie LHP Drew Rom (0-2, 7.24) will face Cincinnati LHP Andrew Abbott (8-4, 3.22) on Friday in the opener of a three-game series in Cincinnati.