Dylan Cease pitched six strong innings and Jurickson Profar had a go-ahead double and a two-run homer among his three hits for the San Diego Padres, who beat the Chicago Cubs 10-2 on Wednesday to take two of three in the series.

Jake Cronenworth also homered to back Cease (1-1), who pitched for the Chicago White Sox for five seasons before being traded to the Padres during spring training. Cease improved to 3-2 against the Cubs. He allowed just two hits and no earned runs while striking out seven and walking two. Chicago had only three hits.

Cease's only big mistake was allowing Michael Busch's tying, two-run homer with two outs in the fourth, his second. It came one batter after shortstop Ha-Seong Kim committed a fielding error on Christopher Morel's grounder.

Cubs LHP Jordan Wicks (0-1, 4.15 ERA) is scheduled to start Friday night in the opener of a three-game series at Seattle, which will counter with RHP Bryce Miller (1-1, 3.00).