The game between the Orioles and White Sox scheduled for Monday night at Camden Yards was postponed after protests over the death of a man injured in police custody turned violent.
The Orioles said the decision to postpone the game was made after consulting with the Baltimore police department.
The team said a makeup date will be announced as soon as possible.
Riots erupted in the city following the Monday funeral of Freddie Gray, who was arrested April 12 and later died after suffering a severe spinal injury.
Maryland Gov. Larry Hogan declared a state of emergency at the request of the city, activating the National Guard to help address the growing violence.
It wasn't the first time an Orioles game was affected by the citywide unrest.
Fans at Camden Yards were asked to stay inside the stadium at the conclusion of Saturday's game against Boston because of safety concerns before they were eventually given the OK to leave.
American League Scoreboard
Kansas City 6, Cleveland 2
Boston 6, Toronto 5
New York 4, Tampa Bay 1
Seattle 3, Texas 1
Detroit 5, Minnesota 4
Houston 9, San Diego 4
>>Hammel Pitches Cubs Past Pirates
Jason Hammel pitched eight shutout innings and Kris Bryant hit a two-run single to lead the Chicago Cubs to a 4-0 win over the Pittsburgh Pirates on Monday night.
Hammel (2-1) bounced back from a loss to Pittsburgh last week to give up just four hits with no walks and seven strikeouts.
Bryant wasn't the only rookie to contribute. Jorge Soler and Addison Russell also chipped in to help the Cubs take the series opener for their third win in a row.
Bryant and Soler had two hits apiece and Russell added one. Soler and Russell both scored a run as Chicago ended Pittsburgh's five-game winning streak, which began with consecutive victories over the Cubs last week.
Vance Worley (2-2) had one of the four hits off Hammel but took the loss, giving up all four Cubs runs in six innings.
>>Hamels Dominates As Phils Get By Cardinals
Ben Revere hit a two-run double during a three-run seventh inning, Cole Hamels tossed seven solid innings and the Philadelphia Phillies beat the St. Louis Cardinals by a 4-1 margin on Monday.
Odubel Herrera went 3-for-4 with an RBI for the Phillies. Hamels (1-2) gave up one run on four hits with nine strikeouts and four walks. The left-hander had been 0-4 with a 3.23 ERA since Sept. 23, 2014.
Matt Holliday drove in the lone run for the Cardinals, who have lost two in a row since a four-game winning streak. John Lackey (1-1) allowed three runs on nine hits over seven innings.
National League Scoreboard
New York 3, Miami 1
Cincinnati 9, Milwaukee 6
Atlanta 8, Washington 4
Colorado 5, Arizona 4
Los Angeles 8, San Francisco 3
Houston 9, San Diego 4
>>Wainwright Out For Season
The St. Louis Cardinals confirmed Monday that ace right-handed pitcher Adam Wainwright will miss the rest of the season with a torn left Achilles, an injury he suffered over the weekend while batting.
Cardinals general manager John Mozeliak held a news conference to announce the results of an MRI and that Wainwright would undergo surgery on Thursday. He is expected to be out of action for 9-12 months.
Wainwright was hurt in the fifth inning of Saturday's game against Milwaukee when he popped up and started to run toward first base.
In four starts this season, the 33-year-old perennial Cy Young contender had a record of 1-2 with a 1.44 ERA.