Eric Fryer had three hits, including a go-ahead double with two outs in the eighth inning during Sunday's 4-3 win over the Cincinnati Reds 4-3.
A backup to All-Star catcher Yadier Molina, Fryer got his first start this season and is 6 for 6 at the plate. Fryer also threw out Brandon Phillips attempting to steal in the sixth.
Michael Wacha gave up one earned run and seven hits.
Matt Carpenter and Jedd Gyorko hit solo homers for St. Louis, which has won three of last four. Ten of the Cardinals' 21 homers this season were hit in the three-game series against the Reds, who have lost five of six.
Mike Leake (0-1) is slated to start the open of a three-game series against the visiting Chicago Cubs.
>>Arenado's Two Homers Lift Rockies Over Cubs
Nolan Arenado hit two home runs, Tyler Chatwood threw seven shutout innings and the Colorado Rockies beat the Chicago Cubs 2-0 on Sunday.
Chatwood, Miguel Castro and Jake McGee combined to hold the Cubs to three hits. McGee struck out Kris Bryant with two runners on base to end it for his third save.
The Rockies took two of three for their first series win at Wrigley Field since 2011. The Cubs were trying to reach 10 wins in the first 12 games for the first time since 1969.
>>Moore Leads Rays Past White Sox
Matt Moore struck out 10 over 6 1-3 innings, Brandon Guyer tied a career high with four hits and the Tampa Bay Rays beat the Chicago White Sox 3-2 on Sunday.
Moore (1-0) allowed two runs and five hits, and improved to 4-1 in five career starts against the White Sox. After Enny Romero worked a perfect inning, Alex Colome got the final five outs for the Rays' first save this season.
Jose Quintana (1-1) gave up three runs, seven hits and had six strikeouts in six innings for Chicago, which has lost two straight after winning five in a row. The left-hander entered with a four-game winning streak dating to last season.
Tampa Bay second baseman Logan Forsythe (bruised left hip and lower leg) and center fielder Kevin Kiermaier (head bruise) were both back in the lineup after missing Saturday's game. They were hurt when they collided chasing a pop fly in shallow right center during Friday night's game.