The New York Giants capitalized on four interceptions of Case Keenum to defeat the Los Angeles Rams 17-10 Sunday in the first NFL game played at London's home of English rugby, a sold-out and raucous Twickenham Stadium.
Keenum, coming off the best start of his career, had the Rams at the Giants' 15-yard line with 50 seconds left when he lobbed a pass in the left corner of the end zone that Dominique Rodgers-Cromartie easily picked off. Keenum's intended target, Brian Quick, failed to get the quarterback's audible and cut off his route early.
Keenum, who finished 32 of 53 for 291 yards and one touchdown, has thrown an interception on the Rams' final offensive play of the last three games. That likely will fuel debate on a potential quarterback change to overall No. 1 draft pick Jared Goff.
The win kept the Giants (4-3) in good shape in the ultra-competitive NFC East, where no one has a losing record. The Rams (3-4) lost their third straight.
Keenum threw two interceptions, both off high-sailing deflections, to safety Landon Collins, and two more in the end zone to cornerback Rodgers-Cromartie. RB Todd Gurley struggled, carrying 15 times for 57 yards, his longest run an 8-yarder.
Collins returned his first pick 44 yards for a second-quarter touchdown, making several Rams miss tackles before he bowled over center Tim Barnes to draw the Giants even.
Collins' second pick set up the winning drive, which featured a 22-yard catch by Odell Beckman Jr. to the Rams 6. Rashad Jennings scored from the 1 for the Giants' only offensive touchdown.
Eli Manning had a pedestrian day, going 24 of 37 for 196 yards and no touchdowns. The Rams managed 20 first downs to the Giants' 13.