Giannis Antetokounmpo and Jabari Parker had 27 points each to lead the Bucks past the Indiana Pacers 125-107.
Antetokounmpo had nine assists and seven rebounds and his running mate, Parker, made a career-high four 3-pointers and grabbed eight rebounds.
Greg Monroe added 16 points, 16 rebounds and six assists, and Tony Snell, the newcomer acquired from the Chicago Bulls for Michael Carter-Williams, had 14 points, including a 3 at the buzzer that gave Milwaukee a 63-57 lead at halftime.
Paul George scored 23 points, reserve C.J. Miles added 19, Jeff Teague had 16 and Myles Turner 15, but it wasn't enough as the Pacers slipped to 0-3 on the road.
Malcom Brogdon, the Bucks' second-round draft pick from Virginia, scored 12 points.
On Saturday, the Pacers look for payback against the Bulls who beat them 118-101 on Oct. 29 in Chicago.