The Indiana Pacers beat the LeBron-less Cleveland Cavaliers 103-92 to improve to 3-1 at home in the past two years when James sits.
Jeff Teague had 20 points and eight assists, and Thaddeus Young had 16 points to help the Pacers improve to 6-1 at home and 6-6 overall.
James sat out for the first time this season. Averaging 23.4 points and 8.9 rebounds, he rested after playing Tuesday night in a home victory over Toronto. Guard J.R. Smith also missed the game because of a sprained right ankle.
Kevin Love led Cleveland with 27 points and 16 rebounds, and Kyrie Irving had 24 points and seven assists. The Cavaliers dropped to 9-2 after matching the best start in franchise history with the victory over Toronto on Tuesday night.
The Pacers host the Phoenix Susn on Friday night to end a four-game homestand.