Thaddeus Young scored 17 points and Paul George added 16 after missing four of the last five games in the Pacers' 111-102 victory on Sunday night that gave them a sweep of the season series for the first time since 2013-14.
Indiana came back from 15 points down in the first quarter and held on after the Clippers got within four in the fourth.
Rodney Stuckey also had 16 points and Jeff Teague added 15 points for the Pacers. CJ Miles had 12 points after missing six games with a sore left knee.
Blake Griffin had 24 points and 16 rebounds for the Clippers, whose two-game winning streak was snapped in their return to Staples Center. They went 3-3 on their recent six-game road trip, including a 91-70 loss at Indiana last week.
Los Angeles led by 15 in the first quarter and appeared on its way to victory, especially when the Pacers missed 15 of 22 shots.
DeAndreJordan had 15 rebounds for the Clippers. Chris Paul added 18 points and 11 assists.
The Pacers visit Western Conference-leading Golden State on Monday night in the second game of a back-to-back.