Mitch Trubisky, the No. 2 overall pick, will make his debut in prime time as the Chicago Bears (1-3) square off against the Minnesota Vikings (2-2).
The 23-year-old Ohio native supplants Mike Glennon as the starter only five weeks into his career.
The Vikings offer a difficult challenge to any quarterback, let alone an untested rookie. Minnesota ranks No. 1 in the league in third-down defense (25.6 percent conversion rate) and tied for eighth in scoring defense (19 points per game).
Vikings defensive end Everson Griffen paces the team with five sacks in the first four games. Safety Andrew Sendejo also has emerged as a leader with 32 tackles and an interception.
Minnesota will play its first game since losing rookie running back Dalvin Cook to a torn left ACL that will cost him the remainder of the season. Cook rushed for 354 yards in three-plus contests.
In Cook's place, running back Latavius Murray will inherit the bulk of the workload. Murray is coming off ankle surgery during the offseason that still has him feeling less than 100 percent.
The Vikings have been without quarterback Sam Bradford for the past three games because of a knee injury. If he remains out, look for Case Keenum to guide the offense once again.
Chicago's defense has offered reason for hope in an otherwise ugly start to the season. The Bears are No. 8 in the NFL in total defense with 306.3 yards allowed per game, however, will be short-handed as linebacker Danny Trevathan serves a one-game suspension for his hit on Green Bay Packers wide receiver Davante Adams in Week 4.