Jonas Valanciunas had 23 points and 15 rebounds, Miles scored 22 points in his Toronto debut and the Raptors beat the short-handed Chicago Bulls 117-101 on Thursday night in the season opener for both teams.
Norman Powell added 15 points, Delon Wright had 13, and Kyle Lowry 12.
Miles went 6 for 9 from 3-point range and had five rebounds. Half of the former Indiana Pacers player's points came in the second quarter during a 22-2 run by Toronto's second unit.
The Raptors were 13 of 29 from long range and had 26 assists on 39 baskets. Lowry had nine assists, and DeRozan and Wright each had five.
Chicago center Robin Lopez scored 18 points, rookie Lauri Markkanen had 17 points and eight rebounds in his NBA debut, and Justin Holiday scored 15.
Chicago opens its home schedule against San Antonio on Saturday night. The Bulls have won six of their past 10 home games against the Spurs.