UMBC's brief, but historic run ended with a 50-43 loss to ninth seeded Kansas State on Sunday night.
UMBC became the first 16 seed to beat a No. 1, destroying top-ranked Virginia 74-54 on Friday night. After pulling off an all-time sports stunner, the Retrievers ran out of magic against the Wildcats.
Barry Brown led Kansas State with 18 points and Xavier Sneed came up with some huge plays down the stretch, including a monster dunk off an offensive rebound.
The Wildcats (24-11) move on to the Sweet 16 for the first time since 2010 when they lost in the Elite Eight to Butler. They will face No. 5 Kentucky on Thursday night.
UMBC had only had two field goals in the final six minutes and shot just 29.8 percent for the game.
UMBC's scrappy defense forced 18 turnovers, but managed just three points off those. They finished 6 of 22 from 3-point range two nights after lighting up Virginia. And 9 of 18 from the free throw line.