The banged-up Warriors again lacked the firepower to finish off an opponent, and Victor Oladipo scored 24 points in the Indiana Pacers' 92-81 victory over the defending champions Tuesday night.
Nick Young scored 12 points as Golden State, playing without its four All-Stars for a second straight game, lost back-to-back contests for only the ninth time during coach Steve Kerr's four seasons.
Thaddeus Young and Bojan Bogdanovic scored 17 points apiece for playoff-bound Indiana, which won its third straight and fourth in five.
Pacers reserve forward Trevor Booker headed to the locker room with 33.5 seconds remaining in the opening quarter with a sprained right ankle and didn't return.
Kevon Looney grabbed a career-best 11 boards off the bench as the Warriors outrebounded Indiana 51-38, but Golden State only managed to shoot nine free throws.
The teams played for the first time, marking the latest the Warriors ever faced an opponent for the first time in a season - their 74th game.