Ryan LaMarre homered and drove in a career-best four runs, Reynaldo Lopez stifled the Yankees again despite diminished velocity and the Chicago White Sox beat New York 4-1 Wednesday night.

LaMarre hit a pair of run-scoring doubles off starter CC Sabathia (7-5), then lifted a leadoff shot against Chad Green in the seventh. The 29-year-old had one previous homer this season and one all of last season between Triple-A and the majors.

Chicago has won five of six and 11 of 15. The rebuilding White Sox took two of three for their first series victory in the Bronx since 2005.

New York is 9-3 in its past 12 but fell 7 1/2 games behind AL East-leading Boston for the best record in the majors. The Red Sox beat the Marlins 14-6.

Jace Fry struck out Gleyber Torres and pinch-hitter Luke Voit with a runner on for his fourth save.

Sabathia struggled through a 32-pitch second inning that included LaMarre's two-run double and an 11-pitch walk to Yolmer Sanchez. LaMarre added his career-best third RBI on a double in the fourth to make it 3-0.

Ronald Torreyes hit a bases-loaded single for New York to make it 3-1 in the fifth, but then Brett Gardner struck out and Torres was thrown out at home on a wild pitch to end the inning. Torres took off after Lopez's pitch skipped past catcher Kevan Smith, but Smith fetched the ball at the backstop and whipped a throw to Lopez for the tag.

Lopez (5-9) allowed a run over seven innings despite lacking his best stuff. Lopez averages 95.5 mph on his fastball but sat at 90-91 in the first inning and only picked it up slightly from there. He was visited by a trainer in the second inning but remained in the game. He allowed five hits, struck out six and walked two.

Lopez also pitched one-run ball over seven innings against New York on Aug. 7.

Chicago starters have a 2.11 ERA over the past six games.

Sabathia allowed three runs over six innings in his second start since returning from the disabled list.