Michael Kopech wasn't sharp and the Tigers took full advantage of the Chicago White Sox's prized pitching prospect.
Ronny Rodriguez had a two-run homer and Jeimer Candelario, Mikie Mahtook and JaCoby Jones each added a solo shot, powering Detroit to a 10-2 rout of the White Sox and Kopech on Wednesday night.
The game was delayed twice by rain for a total of an hour and one minute.
Nicholas Castellanos went 3 for 4 with a walk and an RBI and Victor Martinez had a two-run single as Detroit pounded out 16 hits and won for the eighth time in nine games at Guaranteed Rate Field.
Kopech had allowed just one run in 11 innings in his first three starts in the majors, including two home starts cut short by rain delays. He returned after a short delay on Wednesday and probably wished he hadn't.
Kopech (1-1) was tagged for seven runs on nine hits in 3 1/3 innings. He struck six, walked one and surrendered all four Detroit homers as his ERA jumped from 0.82 to 5.02.
It was a far cry from his effort at Detroit on Aug. 26 when he allowed one run on seven hits in six innings for his first win.
Jordan Zimmermann (7-6) allowed just two hits in five shutout innings and returned following both delays.
Candelario led off the game with a 433-foot homer to set the tone.
Following a 28-minute delay in the bottom of the second, Kopech made quick work of the Tigers in third. The fourth was a different story.
Mahtook, who has homered in back-to-back games, led off with a long blast to left estimated at 455 feet. After James McCann singled, Rodriguez homered to make it 4-0 and Jones followed with a solo blast. It was the second time this season the Tigers have gone back-to-back. Martinez and Niko Goodrum did it on Aug. 30 against the Yankees in New York.
After Dawel Lugo doubled, Kopech struck out Candelario for the first out. The rally, though, wasn't finished. Jim Adduci doubled to plate Lugo for a 6-0 lead and chase Kopech. Castellanos singled off reliever Dylan Covey to score Adduci to cap the six-run inning.
Following a 33-minute delay in the top of the fifth, the Tigers added three in the sixth to make it 10-0, and Chicago added two unearned runs in the seventh.
Up next for the White Sox: Following a day off on Thursday, LHP Carlos Rodon (6-4, 2.89 ERA) pitches the opener of a three-game home series against the Angels and RHP Felix Pena (1-4, 4.19) on Friday night.