JT Realmuto homered and drove in the tiebreaking run with an RBI double in the seventh inning to lift the Phillies to a 3-2 victory over the Chicago Cubs on Tuesday night.

The Phillies will have a familiar face in the dugout Wednesday when new hitting coach Charlie Manuel arrives. The franchise icon was hired to replace John Mallee as hitting coach earlier in the day.

Jason Vargas allowed two runs and five hits in six innings. Blake Parker (2-2) and Mike Morin each tossed a hitless inning and Hector Neris finished for his 21st save in 25 tries. Neris retired Jason Heyward on a grounder to end the game with two runners on.

Cubs starter Jose Quintana had a career-best 14 strikeouts in six innings, allowing two runs - one earned - and five hits. Chicago fell to 23-36 on the road. No other first-place team has a losing record away from home.

Pinch-hitter Andrew Knapp led off the bottom of the seventh with a single off Kyle Ryan (3-2) and scored from first when Realmuto hit a sharp grounder down the left-field line with two outs.

Quinn's RBI triple with two outs in the eighth gave Philadelphia an insurance run.

The Phillies entered the game hitting .229 with two outs and runners in scoring position.

Realmuto hit his 16th homer the opposite way to right to give the Phillies a 2-1 lead in the fifth.

Nicholas Castellanos led off the sixth with his 16th homer to left to tie it at 2-2.

Scott Kingery's sacrifice fly gave the Phillies a 1-0 lead in the third. Castellanos singled leading off the fourth and later scored on Javier Baez's sac fly.

Cole Hamels (6-3, 3.09 ERA) makes his first start against the Phillies in Philadelphia on Wednesday. RHP Aaron Nola (10-3, 3.67) pitches for the Phillies. Hamels, the 2008 NLCS and World Series MVP, was traded from Philadelphia to Texas in July 2015.