J.T. Realmuto hit a grand slam, Bryce Harper went deep twice and the Phillies beat the Chicago Cubs 11-1 in Charlie Manuel's first game as hitting coach, ruining Cole Hamels' return Wednesday night.

Hamels, the 2008 NLCS and World Series MVP with Manuel's Phillies, was roughed up in his first game in Philadelphia since he was traded to Texas in July 2015. Hamels (6-4) gave up eight runs and nine hits in two-plus innings.

Aaron Nola (11-3) benefited from the offense's rare outburst. He allowed three hits, including Kris Bryant's homer, and struck out seven in seven innings.

Harper drove an opposite-field homer out to left-center to give the Phillies a 2-0 lead in the first. His solo shot landed in the second deck in right field in the sixth. Harper has six homers and 11 RBIs in the last 11 games. He's up to 24 homers and 83 RBIs. 

Yu Darvish (4-6, 4.43 ERA) goes for the Cubs and LHP Drew Smyly (2-6, 6.96) starts for the Phillies on Thursday night.