James McCann hit a tiebreaking grand slam in the eighth inning and Chicago outlasted the Houston Astros 13-9 Wednesday to win the season series from the runaway AL West leaders.

McCann lined his 13th homer on an 0-2 pitch from Ryan Pressly (2-3) with two outs into the right field bullpen to end a 16-game stretch without going deep. The All-Star catcher's first homer since July 22 was his fourth career grand slam and lifted Chicago to a wild victory after the Astros rallied late to tie it.

Rookie Eloy Jimenez hit his 20th homer and doubled, and Tim Anderson doubled twice among four hits for the White Sox.

Following a doubleheader split on Tuesday, Chicago (54-65) took two of three games from the Astros in a little over 24 hours and finished 4-3 against them this year. Houston has lost three of four following an eight-game winning streak.

Jose Altuve hit a two-run homer off Evan Marshall in the Astros eighth to tie it at 9.

Chicago also overcame a pair of solo shots by Yuli Gurriel and a four-hit day by Michael Brantley that included two doubles. Alex Bregman drove in three runs for Houston after missing Tuesday's twinbill with a sore shoulder.

Jose Abreu and Welington Castillo each had two RBIs for the White Sox.

Alex Colome (4-2), the fifth Chicago reliever, finished the game with 1 2/3 scoreless innings.

Houston starter Wade Miley allowed seven runs (three earned) on nine hits and hurt himself in the field.

Chicago starter Ross Detwiler allowed four runs on six hits and two walks in 4 2/3 innings and left with a 7-4 lead.

Reynaldo Lopez (7-9, 5.16) takes the mound at Anaheim against Angels LHP Andrew Heaney (1-2, 4.89) on Thursday. Lopez tries for his third straight win and is 3-1 with a 2.13 ERA in his last six starts.