Keston Hiura homered and drove in three runs, Jordan Lyles turned in another strong start and Milwaukee snapped St. Louis' six-game winning streak with a 4-1 victory Wednesday.
The Cardinals had won 15 of 18, including two at Miller Park this week in matching their longest winning string of the season.
The Brewers ended a three-game skid. Third in the division, they trail the Cardinals by 5 1/2 games.
Milwaukee got off to a fast start against Jack Flaherty (8-7), who had given up a total of just one run in his previous five starts.
Trent Grisham led off the first inning with a single, went to third on a throwing error by second baseman Kolten Wong and scored on a groundout by Hiura. Milwaukee made it 2-0 in the second when Ryan Braun doubled and later scored on Orlando Arcia's sacrifice fly.
Hiura hit a solo home run in the fourth, sending a 3-0 fastball from Flaherty into the left-field seats. Hiura added an RBI double in the eighth.
Lyles (9-8), acquired from Pittsburgh in a trade on July 29, set the tone for Milwaukee. The right-hander, who had held Arizona hitless in a six-inning outing in his last start, struck out five of the first seven Cardinals he faced. He fanned nine in 5 1/3 innings.
Yadier Molina hit two singles and went 7 for 11 in the series.
Wong hit his 10th homer, connecting in the sixth off Lyles. He also doubled and singled.
Christian Yelich singled and walked in four plate appearances. The reigning NL MVP hasn't hit a home run in 10 games, his longest drought of the season for Milwaukee.
A three-day, four-game series against the Reds starts Friday in St. Louis. Cardinals RHP Dakota Hudson (13-6, 3.47 ERA) faces Reds RHP Trevor Bauer (10-11, 4.34 ERA) in the opener. Saturday features a day-night double-header.
