Christian Yelich hit a three-run homer off Craig Kimbrel in the ninth inning, and Milwaukee beat Chicago 4-0 on Sunday for its second straight shutout against the Cubs.
After Gio Gonzalez walked four in three hitless innings, Jay Jackson (1-0) got six outs for his first major league win. Drew Pomeranz got two big outs in the eighth before Josh Hader finished the four-hitter.
The Brewers were clinging to a 1-0 lead before Yelich connected with two outs in the ninth, driving a full-count pitch deep to center field.
Tyler Chatwood (5-3) replaced Darvish and allowed the game's first run on Orlando Arcia's groundout in the fourth. Ben Gamel set up the play when he went from first to third on Cory Spangenberg's one-out single to left-center.
The Cubs left nine on base and went 0 for 10 with runners in scoring position. Kris Bryant led off the eighth with a single and advanced to second on a wild pitch. But Junior Guerra fanned Victor Caratini before Pomeranz struck out Anthony Rizzo and Jason Heyward to end the inning.