Chris Paddack pitched six strong innings and the San Diego Padres beat the Cubs 4-0 Wednesday night, dropping Chicago into a tie with Milwaukee for the second NL wild-card spot. Manuel Margot homered off San Diegan Cole Hamels and also made a spectacular catch in center field.

The Cubs lost for the second straight night and for the fifth time in six games. Milwaukee beat Miami 7-5 in its first game since reigning MVP Christian Yelich suffered a season-ending knee injury.

Philadelphia and the New York Mets are two games behind the Cubs and Brewers.

Hamels (7-7) didn't get out of the fifth. The left-hander, who went to Rancho Bernardo High, allowed one run on four hits, struck out six and walked four in 4 1/3 innings.

Paddack (9-7) held Chicago to three hits while striking out seven and walking one.

Wil Myers hit a two-run single in the seventh.

Yu Darvish (5-6, 4.12) is scheduled to make his team-high 29th start in the series finale Thursday. He's 2-1 with a 4.13 ERA in four career starts against the Padres.

Dinelson Lamet (2-4, 3.95) has allowed three earned runs or fewer in nine of his 11 starts, while striking out five or more in 10 starts.