Antonio Senzatela pitched six strong innings for his first win since July 14, Ian Desmond hit a go-ahead home run and the Colorado Rockies beat the St. Louis Cardinals 2-1 Wednesday night.

The Cardinals loaded the bases loaded with one out in the first when Senzatela induced Paul DeJong to ground into an inning-ending double play, producing an immediate lift for the pitcher.

Tony Wolters had two hits, including an RBI double. Paul Goldschmidt had an RBI double for the Cardinals' run.

Senzatela (9-10) allowed a run on four hits. He struck out five and walked two in his first win since July 14. It was an abrupt reversal of form for Senzatela, who entered 0-3 with a 15.83 ERA since returning Aug. 25 from a stint with Triple-A Albuquerque.

Dakota Hudson (15-7) pitched nearly as well, allowing two runs on four hits in six innings. He struck out seven and walked five, one intentionally, and saw his career-high five-game winning streak snapped.

Miles Mikolas (8-13, 4.25 ERA) makes his second career start at Coors Field. Allowed career-high 12 hits in his only previous start at Coors Field a year ago in which he also homered and did not figure in the decision.

Tim Melville (2-1, 3.66 ERA) is slated to make his fifth start of the season. Rockies have come out on top in three of his four outings.