Jose Iglesias had an RBI double in the 10th inning and five Cincinnati pitchers combined for a four-hitter as the Reds recorded their second straight win over playoff-contending Chicago 3-2 on Wednesday night.

The Cubs and Milwaukee Brewers trail the NL Central-leading St. Louis Cardinals by three games. Chicago and Milwaukee are tied for the second NL wild-card spot, 1 1/2 games behind the Washington Nationals, who hold the first wild card.

Chicago opens a four-game series against St. Louis on Thursday night at Wrigley Field.

With two outs and none on in the top of the 10th, Cincinnati's Aristides Aquino started the winning rally against James Norwood (0-1) with a single to left. After Aquino advanced on a wild pitch, Josh VanMeter walked, putting runners on first and second. Iglesias then doubled to right to score Aquino with the go-ahead run.

Amir Garrett (5-3) struck out Kyle Schwarber to end the ninth and Raisel Iglesias worked around a one-out double in the 10th for his 33rd save. Nico Hoerner lined out to right to end it.

Reds slugger Eugenio Suarez hit his 48th homer, one behind Pete Alonso of the New York Mets for the major league lead. The total is the most ever by a Venezuelan player, breaking the previous mark of 47 by Andres Galarraga.

Suarez also tied the NL record for homers by a third baseman. Mike Schmidt of the Phillies (1980) and Adrian Beltre of the Dodgers (2004) are the others reach the mark.

Cincinnati starter Tyler Mahle allowed just one run on one hit in six innings.

Jon Lester allowed one run on six hits in five-plus innings.

Kyle Hendricks (11-9, 3.26 ERA) starts the opener of the St. Louis series Thursday night with RHP Jack Flaherty (10-8, 3.05) going for Cardinals. Hendricks has a 1.75 ERA in 13 home starts, while Flaherty is 6-2 with a 0.90 ERA in his last nine starts.