The Pacers snapped the Raptors' five-game win streak with a 120-115 overtime triumph on Monday.
Aaron Holiday's fourth 3-pointer of the game gave the Pacers a 116-113 lead with 2:05 remaining in overtime. His fifth and final 3-pointer provided a 119-115 advantage with 54 seconds remaining.
Lowry managed just two points in overtime when the Pacers outscored the Raptors 13-8.
Serge Ibaka added 23 and Fred VanVleet 21 for the Raptors
The Pacers' Myles Turner sank 5 of 6 3-pointers in finishing 9 of 12 from the floor.