Domantas Sabonis matched a season high with 29 points and added 13 rebounds and six assists to lead Indiana over the Timberwolves 104-99 on Wednesday night.
Malcolm Brogdon added 21 points in his second game back from injury and Doug McDermott scored 14 off the bench for the Pacers, who have won three straight games.
Jarrett Culver led Minnesota with 17 points and Gorgui Dieng had 15 points and 11 boards. The Timberwolves have lost three in a row.
Brogdon had 16 of his 21 points after halftime, including 10 in the fourth quarter.
Minnesota led by nine in the first half after a basket by Andrew Wiggins. The Timberwolves took a 59-54 lead into halftime but saw that lead momentarily disappear in the third before holding a one-point lead after three.
Culver trimmed Indiana's lead on consecutive possessions late in the fourth, but the Pacers had an answer each time. After a basket by Culver made it a three-point game, Brogdon hit his first 3-pointer of the game to push the lead to six.
Wiggins was held scoreless in the second half on 0-of-5 shooting for Minnesota after 10 first-half points.
McDermott scored 10 of his 14 points in the final quarter.
Minnesota's bench outscored Indiana's reserves 39-26, led by 15 points from Bloomington-product Keita Bates-Diop.
The Pacers host Minnesota on Friday night.