Malcolm Brogdon thwarted Milwaukee's charge with a nearly perfect fourth-quarter performance, helping the Pacers hold on for a 118-111 victory while snapping a season-worst six-game losing streak.
Brogdon finished with 17 points and matched his career-high with 13 assists, but saved his best for the final quarter when he scored 10 points, recorded five assists and making all four of his free throws.
As Milwaukee methodically cut a 25-point first-half deficit to five early in the fourth, it seemed another game might get away from the Pacers. But Brogdon scored on back-to-back baskets and found Jeremy Lamb for a layup.
When the Bucks made it 90-86 with 8:18 to go, Brogdon found Lamb and T.J. Warren for back-to-back 3-pointers and closed out the 10-0 run by making two free throws and a 14-foot runner to give Indiana a 100-86 lead with 6:19 to go.
T.J. Warren led the way with 35 points as the Pacers ended a five-game home losing streak and a four-game skid in the series against the Bucks.
While it helped that reigning league MVP Giannis Antetokounmpo missed his second straight game following the birth of his first child.
And the Pacers' fast start didn't hurt, either.
The difference this time: Indiana steadied itself when the Bucks got within 82-71 at the end of the third quarter and opened the fourth with six straight points before Brogdon became the closer.
Milwaukee had a five-game winning streak snapped and lost its first game against a Central Division foe this season after winning the first 11.
George Hill (strained left hamstring) and Kyle Korver (sore back) also missed the game.
First-time All-Star Domantas Sabonis had 15 points and eight rebounds, while Myles Turner had 14 points and 10 rebounds.
Oladipo and Jeremy Lamb each scored 13 points, and Warren had four steals for Indiana.
The Pacers visit New York on Feb. 21, following the All-Star break.