Josh Donaldson homered and drove in two runs in his Target Field debut with Minnesota, Jorge Polanco hit a two-run shot and the Twins beat the St. Louis Cardinals 6-3 in their home opener on Tuesday night.

Homer Bailey (1-0) pitched five innings in his first start for the Twins, allowing a two-run homer to Tyler O'Neill in the fifth. Bailey had a 6-0 lead before that thanks in part to Donaldson, the heralded addition to an already potent lineup who signed a four-year, $92 million contract during the winter.

Cardinals starter Carlos Martinez (0-1) was pulled after 3 2/3 innings, when the homer by Donaldson ended his night. Polanco's drive capped a five-run second for the Twins, with Max Kepler delivering an RBI single and Donaldson contributing a sacrifice fly.

The stumble by Martinez was ill-timed, considering the Cardinals placed Miles Mikolas on the injured list before the game with a tendon injury in his forearm that needs surgery and will knock him out of the rotation for the entire season.

Tommy Edman took Trevor May deep in the eighth for the Cardinals, despite 2017 Gold Glove winner Byron Buxton's well-timed jump from the back of the warning track in center field. The ball simply bounced off the bottom of his mitt and onto the grass berm beyond the wall, prompting an incredulous expression from Buxton as he dropped to his knees in disgust over missing the catch.

Matt Carpenter, who fouled a pitch off his left knee Sunday, was back in the lineup. He went 2 for 4. 

Daniel Ponce de Leon will take the mound Wednesday night in place of Mikolas. Ponce de Leon has a 3.29 ERA over 82 career innings, including 12 starts.

Rich Hill makes his first start with the team in the finale of the two-game series. Hill, who used the pandemic pause to recover from offseason elbow surgery, had his turn pushed back three days for extra rest. The 40-year-old spent the last four seasons with the Los Angeles Dodgers.