Francisco Lindor and Bradley Zimmer each homered and drove in two runs, propelling the Cleveland Indians to a 4-3 victory over the Chicago White Sox in the first game of a doubleheader on Tuesday.

Aaron Civale (1-0) struck out a career-high nine and allowed two runs over six innings in his first start of the season. Brad Hand gave up an RBI single to Yasmani Grandal in the ninth before picking up his second save for the Indians, who never trailed.

Lindor hit a two-run homer in the first inning and Zimmer had a solo shot in the second as Cleveland took a 3-0 lead off Dylan Cease (0-1). Zimmer added an RBI single in the third to make it 4-1.

Tim Anderson, last year's AL batting champ, went 3 for 5 with a third-inning homer, two doubles and all three of Chicago's runs. Jose Abreu's RBI groundout in the fifth scored Anderson, cutting the Indians' lead to 4-2.

The White Sox loaded the bases with one out in the eighth against Nick Wittgren, but Leury Garcia hit into a fielder's choice and Zack Collins flied out.

Cease gave up four runs and seven hits in 2 1/3 innings. Five relievers combined to blank Cleveland the rest of the way.

Carlos Santana hit a three-run homer, Oscar Mercado had a two-run single and the Cleveland Indians beat the Chicago White Sox 5-3 to complete a doubleheader sweep on Tuesday night.

Santana's first inning blast helped spoil the return of White Sox pitcher Carlos Rodon (0-1) from Tommy John surgery. The left-hander gave up five runs in 3 2/3 innings in his first appearance since May 1, 2019.

Mercado drove in Franmil Reyes and Domingo Santana in the fourth, extending Cleveland's lead to 5-1. James McCann hit a solo homer for Chicago in the second, and Jose Abreu added another in the sixth off right-hander Adam Plutko (1-0).

Abreu, who went 3 for 4, doubled in the eighth and scored on Nicky Delmonico's single that pulled the White Sox within 5-3. Zack Collins followed with a drive to the wall in center, but Mercado made a tremendous leaping catch to end the inning.

Rookie Cam Hill earned his first save with a perfect ninth. Plutko struck out four over six innings in his season debut.

Carlos Santana and Jose Ramirez had two hits apiece for the Indians, who have won three in a row. Santana reached base in all four plate appearances in the opener and played all 18 innings at first base.

White Sox rookie CF Luis Robert raced to straight-away right and stepped in front of RF Leury Garcia to catch a routine fly ball in the fifth inning of the nightcap.

Eloy Jimenez (head) took batting practice and ran the bases but was held out of both games. The 23-year-old slugger was hurt Sunday when he crashed into the left-field wall against Minnesota.

Lucas Giolito (0-1, 17.18 ERA) allowed seven runs in 3 2/3 innings on opening day against Minnesota. He has thrown 14 2/3 consecutive scoreless frames against the Indians.

Shane Bieber (1-0, 0.00 ERA) starts the three-game series finale Wednesday. The 2019 All-Star Game MVP struck out 14 over six scoreless innings against Kansas City on opening day.