Mike Moustakas and Nick Senzel homered in their returns from a COVID-19 scare, Nick Castellanos added a grand slam, and the Cincinnati Reds ended a four-game losing streak by beating the Chicago Cubs 12-7 Wednesday night.

Sonny Gray (2-0) extended his major league record to 35 consecutive starts allowing six hits or less. He gave up only Ian Happ's double and fanned 11 as he pitched into the seventh inning.

Moustakas and Senzel missed the last three games after feeling sick a day after teammate Matt Davidson went on the injured list because he tested positive for the coronavirus. After passing tests, they returned and helped the Reds to their best run total of the season.

Kyle Hendricks (1-1) threw a three-hit shutout against the Brewers in the season opener but couldn't make it through the fifth inning against Cincinnati. Moustakas had a two-run shot in the fourth, and Hendricks left after Eugenio Suarez's bases-loaded single an inning later.

Castellanos connected for his fifth career grand slam off Rex Brothers, and Senzel added a solo shot in the 27-minute half-inning.

Hendricks gave up seven hits and six runs in 4 1/3 innings, his second straight rough outing at Great American Ball Park. He allowed seven runs in 2 2/3 innings of a 10-1 loss last Aug. 10.

Yu Darvish (0-1) is 3-2 in eight career starts against the Reds with a 3.60 ERA. He gave up six hits and three runs in a loss to the Brewers in his first start.

Luis Castillo (0-0) is 4-2 in 10 career starts against the Cubs with a 3.56 ERA. In his start against the Tigers on Saturday, he gave up one run and six hits in six innings.