Jose Abreu hit a tie-breaking homer in the eighth inning, then Edwin Encarnacion followed with his second solo shot of the game to lift Chicago over the Detroit Tigers 5-3 on Wednesday night, the White Sox fourth straight win.

Abreu lofted the first pitch he faced from Gregory Soto (0-1) just over the wall in right to give Chicago a 4-3 lead with one out. Encarnacion then sent a drive to left-center for his 37th career multi-homer game, sealing the Tigers' eighth loss in row.

The right-handed hitting Abreu at first thought he had just poked a deep opposite-field fly. Through an interpreter, he said he realized he had homered ''when it was gone.''

Evan Marshall (1-1) pitched a perfect eighth for the win. Alex Colome followed with a 1-2-3 ninth for his sixth save.

Prized right-handers Casey Mize and Dane Dunning started impressively in their major league debuts before running into trouble and exiting in the fifth inning with nearly identical lines.

Encarnacion hit a long solo shot off Mize in the second. Jeimer Candelario tagged Dunning for a towering three-run drive with one out in the fifth that put Detroit ahead 3-1 and ended 25-year-old's first outing since undergoing Tommy John surgery in March 2019.

Mize, the No. 1 pick overall in the 2018 draft, allowed three runs on seven hits, while striking out seven and walking none in 4 1/3 innings. The 23-year-old was replaced by Jose Cisnero after Yoan Moncada's RBI single tied it at 3.

Dunning also yielded three runs on five hits and struck out seven while walking one through 4 1/3.

Candelario lined Dunning's first pitch of the game to the wall in right for a double, but the big righty set down the next 11 hitters, fanning six of and striking out the side in the third.

Encarnacion launched Mize's hanging curve deep to left for his third homer to lead off the second. Nomar Mazara followed with a line-shot double off the left-field wall. But Mize retired nine of the next 10 Chicago hitters.

Dunning was nursing a 1-0 lead until Candelario's towering fly narrowly cleared the wall in right center to make it 3-1.

Detroit's RHP Spencer Turnbull (2-1, 2.78) faces Chicago RHP and ace Lucas Giolito (1-2, 4.88) in the series finale on Thursday afternoon. Giolito will try to rebound from a loss against St. Louis last Saturday when he allowed four runs in the first inning.