Shane Bieber lowered his ERA to 1.63 in his final regular-season start, the lowest in the American League since Luis Tiant's 1.60 for Cleveland in 1968, and Jordan Luplow hit a game-ending home run that gave the Indians a 3-2 win over Chicago on Wednesday night.

The loss dropped the White Sox in second place in the AL Central at 34-22, a half-game behind Minnesota (35-22). Chicago has lost a season-high four in a row and us 1-5 on a seven-game trip.

Bieber, who leads the big leagues with eight wins, allowed an unearned run and two hits in five innings with 10 strikeouts. The right-hander also is first in baseball with 122 strikeouts and eight double-digit strikeout games.

Cleveland closed within two games of the first place with their second straight last at-bat victory. Jose Ramirez hit a three-run homer with two outs in the 10th for a 5-3 win Tuesday to clinch a playoff spot.

With the score 2-2, Luplow homered onto the porch in left field off Gio Gonzalez (1-2). Luplow, a .194 hitter, struck out in his first three at-bats and followed with his second home run of the season.

Brad Hand (2-1) earned the win with a perfect ninth.

White Sox starter Lucas Giolito gave up two runs and four hits in six innings, striking out 11. 

Carlos Santana hit a 441-foot home run in the second and with 215 homers tied Hall of Famer Larry Doby for sixth place on the Indians list.

Edwin Encarnacion had an RBI groundout that tied the score in the fourth by bringing home Jose Abreu, who reached on an error by Ramirez at third.

Dallas Keuchel (6-2) had a no-decision on Sept. 19 at Cincinnati, throwing four scoreless innings in his return from a stint on the injured list caused by back spasms.

Zach Plesac (4-2, 1.85 ERA) has not allowed a run in two starts against the White Sox this season, striking out 18 without a walk over 14 innings. Plesac, who will not have enough innings to qualify for the ERA title, will be pitching on five days' rest for the second straight outing.