Duncan Robinson and Jimmy Butler combined for the first six points in a decisive fourth quarter run and then helped Miami hold Indiana to five points over the final seven minutes for a 92-87 victory.
Robinson finished with 20 points, eight rebounds and four assists, making six 3-pointers. Butler had 18 points as Miami won its second straight and avoided a three-game sweep in the season series with the Pacers.
Indiana was led by Myles Turner with 15 points and Caris LeVert and Doug McDermott, who each had 14. The Pacers have lost two straight overall and seven of their last eight at home. This one came like so many others recently - a bad fourth quarter.
Miami spent most of the night playing catch-up and finally overtook Indiana when Robinson made his fifth and sixth 3-pointers for a 79-78 lead with 7:44 to go. After trading baskets and the lead for several possessions, Butler and Robinson swung the game with three straight buckets, and Bam Adebayo's 7-footer with 1:06 left made it 89-82.
The Heat defense took care of the rest.
Indiana led 45-32 in the second quarter but Miami scored the final 11 points of the half to get within 45-43. The Pacers answered by scoring the first 13 points of the second half then gave up 11 straight as the Heat pulled within 58-54 midway through the third and got as close as 67-65 after three.
Adebayo finished with 16 points, extending his career-long streak of consecutive double-figure games to 34. He also had eight rebounds and seven assists. Robinson also had eight rebounds.
Tyler Herro had 17 points.
Pacers All-Star Domantas Sabonis came up just short of his customary double-double with 14 rebounds and nine points.
The Pacers host Charlotte on Friday.