Willson Contreras, Javier Baez and David Bote homered during a four-run fourth inning to lift the Chicago Cubs over the Milwaukee Brewers 5-3 on Monday night.
Trevor Williams pitched perfectly until Omar Narvaez's leadoff single in the sixth. Narvaez added a three-run homer in the seventh.
Williams (1-0) was making his Cubs debut after five seasons with Pittsburgh. He pitched into the seventh, allowing two runs, two hits and two walks while striking out six.
Alec Mills, who no-hit Milwaukee as a starter last September, pitched the ninth for his first save.
Brett Anderson (0-1) allowed all of Chicago's homers, giving up four runs and four hits over five innings while striking out four.
Neither team had a baserunner until the bottom of the fourth, when Ian Happ drew a leadoff walk from Anderson. Contreras came up next and knocked him home with a drive that just cleared the center field fence. Baez later homered to right-center, and Bote followed with a blast to deep center.
The Brewers have 39 strikeouts, 10 hits and five runs in their last 27 innings.