Willson Contreras hit a go-ahead homer, Patrick Wisdom went deep for the third time in two games and the surging Cubs beat San Diego 4-3 on Tuesday night after Padres star Fernando Tatis Jr. left with an injury.

Tatis exited because of right oblique tightness. He hit a fly to left field in the sixth inning and was replaced at shortstop in the bottom half by Ha-Seong Kim.

The NL Central-leading Cubs are feeling good about themselves after winning for the eighth time in nine games. They secured a series victory against one of baseball's top teams and put themselves in position to complete a three-game sweep.

Patrick Wisdom, who homered twice in Monday's win, and Contreras each hit a long two-run drive against Ryan Weathers (2-2).

Wisdom sent one to the back of the left-field bleachers in the second inning. Contreras put Chicago back on top 4-3 with a 445-foot shot to center in the fifth after former Cub Victor Caratini and Tommy Pham homered against Kyle Hendricks (6-4) in the top half.

Rizzo singled twice for Chicago after missing the previous six games because of back tightness. Kris Bryant went 0 for 4, snapping his 13-game hitting streak.

Hendricks won his fourth straight start. The right-hander went six innings, allowing three runs and seven hits.

Ryan Tepera and Andrew Chafin each pitched a scoreless inning. Craig Kimbrel struck out all three batters in the ninth for his 13th save in 15 chances, delighting the crowd of 24,824.

The three-game series wraps up Wednesday with Adbert Alzolay (3-4, 3.81 ERA) starting for Chicago against RHP Dinelson Lamet (1-0, 2.57). Alzolay pitched scoreless ball into the sixth inning of a win over Cincinnati on Friday. Lamet went three innings, allowing two runs, in San Diego's 10-3 victory at Houston last week.