Jesse Winker hit a two-run homer, Vladimir Gutierrez earned his first career win and the Cincinnati Reds beat the St. Louis Cardinals 4-2 on Thursday night.

Gutierrez (1-1) pitched five innings of two-run ball, settling down nicely after a shaky start. He allowed three hits, struck out three and walked three in his second big league game.

Tejay Antone followed Gutierrez with two scoreless innings, and Lucas Sims got six outs for his fourth save.

St. Louis got two in the first on RBI singles by Tyler O'Neill and Yadier Molina. O'Neill extended his hitting streak to a career-best 11 games.

But Cincinnati went ahead to stay on Winker's 14th homer in the second, a drive to right against Adam Wainwright that traveled an estimated 425 feet.

Winker finished with three hits, and Nick Castellanos extended his hitting streak to 19 games with a first-inning single. Tucker Barnhart added an RBI double in the eighth.

Barnhart helped thwart a Cardinals rally in the ninth by pouncing on a Jose Rondon bunt and starting a 2-5-3 double play. After Paul Goldschmidt walked, putting runners on first and second, Tommy Edman struck out to end the game.

Wainwright (3-5) permitted three runs and eight hits in seven innings. He hit a career-high three batters, including Tyler Naquin with the bases loaded in the first.

The Cardinals lost for the fourth time in five games.

Wainwright got some help from his defense in the fifth when Dylan Carlson, Tommy Edman and Molina executed a perfect 8-4-2 putout on Tyler Stephenson as he tried to score on a Naquin double.

Reds right-hander Luis Castillo (1-8, 7.22 ERA) starts Friday night against Cardinals left-hander Kwang Hyun Kim (1-3, 3.65 ERA). Castillo is seeking his first win since April 7. Kim is making his fourth career start against Cincinnati after winning his first three outings.