Pinch-hitter Erik Gonzalez's two-run single highlighted a four-run rally in the seventh inning as the Pittsburgh Pirates beat the skidding Chicago White Sox 6-3 on Tuesday night.

A three-run homer by pinch-hitter Yasmani Grandal in the top of the seventh put the White Sox ahead 3-2 after they were held scoreless on two hits through six innings.

But the Pirates answered in the bottom half against rookie reliever Garrett Crochet (2-4), who was charged with four runs without getting an out.

Gonzalez's hit put Pittsburgh ahead 5-3 and helped extend Chicago's losing streak to five games, the longest of the season for the AL Central leaders. The Pirates have won three of four since a 10-game losing streak.

The White Sox are rolling in the wrong direction. They were swept in a four-game series at Houston last weekend, getting outscored 27-8 by the Astros.

Frazier homered for the Pirates, and Bryan Reynolds had two hits and two RBIs.

David Bednar (1-1) got the last out of the seventh for his first major league win. Richard Rodriguez earned his ninth save in 11 tries with a 1-2-3 ninth as the Pirates won for the third time in four games.

Grandal's home run off starting pitcher Tyler Anderson was his 11th of the season and fourth as a pinch-hitter in his 10-year career. The lead didn't last long after Giolito was removed for a pinch-hitter later in the inning.

Gregory Polanco and Phillip Evans hit back-to-back singles to start the Pittsburgh seventh. Kevin Newman then beat out a bunt for a single and Polanco scored the tying run when third baseman Yoan Moncada made a wide throw to first for an error.

Gonzalez followed by grounding his go-ahead single into left field. Reynolds added an RBI single later in the inning to make it 6-3.

Anderson allowed three runs and five hits in 6 1/3 innings with four strikeouts and one walk. In six innings, Giolito gave up two runs on four hits while striking out seven and walking two.

Giolito threw a no-hitter against the Pirates last season in Chicago.

Frazier helped the Pirates take a 2-0 lead. He hit a solo home run in the third and walked and scored on Reynolds' single in the sixth.

Dylan Cease (5-3, 3.99 ERA) is scheduled to face RHP Chase DeJong (0-1, 4.26) on Wednesday in the finale of the two-game series. Cease is 2-3 with a 6.89 ERA in seven road starts this season.