Miguel Cabrera and Robbie Grossman hit back-to-back home runs to lead the Detroit Tigers to a 4-3 interleague victory over the St. Louis Cardinals on Tuesday night.

Two days after hitting his 500th homer, Cabrera connected on No. 501. He crushed a 79-mph slider by starter Jack Flaherty into Big Mac Land, which is the name of the upper left field deck, in the third inning. At 423 feet, it was his second-longest home run this season.

The Cardinals immediately removed Flaherty (9-2) with what the team said was right shoulder tightness. In two innings, Flaherty allowed four runs on four hits with three walks on 46 pitches. He velocity dropped dramatically after the first inning.

Casey Mize (7-6) pitched five scoreless innings. He checked the Cardinals on three hits.

The Cardinals scored three runs in the eighth off Erasmo Ramirez. Harrison Bader, who led off with a triple, scored on a ground out. Nolan Arenado hit a two-run, two-out double off Fulmer, who then struck out Yadier Molina to end the inning.

Tarik Skubal (8-11, 4.02) went 6 2/3 innings in his last start, giving up six hits, zero walks and two earned runs while striking in a loss in his last start against the Los Angeles Angels.

Jon Lester (4-6, 6.02 ) will make his 14th career start against the Tigers and first with the Cardinals. He pitched 4 1/3 innings in his last start, allowing six hits and three walks for four earned runs in a no decision against the Milwaukee Brewers.