Already accustomed to playing without their top pass rusher, the Green Bay Packers now must prepare for the likely absence of their best cornerback.

Jaire Alexander injured a shoulder in the second half of the Packers’ 27-17 victory over the Pittsburgh Steelers on Sunday. Without getting into specifics, Packers coach Matt LaFleur said Monday he had spoken with head athletic trainer Bryan Engel and team physician Patrick McKenzie about Alexander’s situation.

When LaFleur was asked if he could rule out a worst-case scenario, he replied that “everything's kind of getting looked at right now.”

If Alexander misses significant time, it would represent arguably the toughest blow yet for a team already dealing with multiple injuries.

Outside linebacker Za’Darius Smith, who had a combined 26 sacks in 2019-20, hasn’t played since a season-opening 38-3 loss to the New Orleans Saints and might miss the rest of the season.

Left tackle David Bakhtiari, a 2020 All-Pro selection, hasn’t played all season and will miss at least two more games as he recovers from a torn anterior cruciate ligament. Wide receiver Marquez Valdes-Scantling went on injured reserve with a hamstring issue last week and must miss at least two more games.

The Packers (3-1) played without guard/tackle Elgton Jenkins (ankle) for a second straight game Sunday and also were missing linebacker Krys Barnes and cornerback Kevin King due to concussions.

Through it all, the Packers have won three straight games to lead the NFC North. They’ve beaten San Francisco and Pittsburgh the past two weeks while missing their two best offensive linemen.