Playing without stars Giannis Antetokounmpo and Khris Middleton, the Milwaukee Bucks leaned on Jrue Holiday and had a 21-0 fourth-quarter run to beat the Indiana Pacers 114-99 on Wednesday night.

Holiday had 26 points and 14 assists.

Tied at 87 after three quarters, Milwaukee surged ahead early in the fourth quarter with the big run. The Bucks raced to a 112-92 lead with just over three minutes left, with Pat Connaughton and Jordan Nwora each scoring eight points during the run. Both finished with 20 points.

Antetokounmpo, averaging 27 points, 11.6 rebounds and 5.8 assists, entered the league's health and safety protocols list Tuesday. Middleton, averaging 17.8 points, exited with a hyperextended left knee late in the third quarter Monday night in Boston.

Domantas Sabonis had 16 points and 14 rebounds for Indiana. Caris LeVert scored 14 of Indiana's first 20 points and finished with 16.

Milwaukee has won five of its last eight. It has won seven straight against Indiana. Indiana had won three of its previous four games, following a four-game losing streak.

Indiana coach Rick Carlisle missed his third game since testing positive for COVID-19. Assistant Lyd Pierce filled in.

Budenholzer said he did not know how long Antetokounmpo would be out, but said Middleton could return Friday night at New Orleans

The team has not said whether Antetokounmpo tested positive for COVID-19. Antetokounmpo said at the league's media day in September that he was vaccinated.

The Pacers host Detroit on Thursday night.