Giannis Antetokounmpo had 25 points and 17 rebounds in his return to action and the Milwaukee Bucks extended their recent mastery of the Chicago Bulls with a 126-98 blowout on Tuesday night.

Antetokounmpo missed the Bucks' 138-119 loss at Minnesota on Saturday due to a sore right knee. Milwaukee played without All-Star forward Khris Middleton, who was dealing with a sore left wrist.

Jrue Holiday had a game-high 27 points to go along with seven assists and no turnovers as the Bucks won for the 15th time in their last 16 meetings with the Bulls, including all three matchups this season. Chicago's lone win during that stretch came in the 2019-20 regular-season finale, when the Bucks rested their starters because they were locked into the East's No. 3 playoff seed.

Brook Lopez had 10 points and six rebounds in 24 minutes for Milwaukee after making his first start since the season opener. The 7-footer had come off the bench for the Bucks' last three games after missing 67 due to a back injury that required surgery.

The Bucks shot 61% from the floor and had seven players score in double figures. The Bulls shot just 42.4%.

Nikola Vucevic had 22 points for the Bulls, who opened a five-game trip one night after a 113-99 victory over the Toronto Raptors. DeMar DeRozan and LaVine added 21 points each as the Bulls lost for the ninth time in 12 games.

Milwaukee took command with a 23-4 spurt that began late in the first quarter and continued in the second.

After trailing by 23 late in the second period, the Bulls cut the lead to 64-54 early in the third. But the Bucks regrouped and pulled away again, eventually leading by as many as 35.

Milwaukee's Serge Ibaka and Chicago's Tristan Thompson each received technical fouls late in the fourth quarter after they got into a brief tussle on an inbounds pass attempt.

The Bulls are at New Orleans on Thursday. The Bulls beat the Pelicans 128-112 in Chicago on Oct. 22.