The Cincinnati Reds ended an 11-game losing streak, their longest in six years, jumping to a first-inning lead and beating the St. Louis Cardinals 4-1 on Sunday as former first-round draft pick Nick Lodolo got his first major league win.

Colin Moran drove in two runs for the Reds, who had been 0-4 at home this year and had not won anywhere since April 10 at World Series champion Atlanta. Cincinnati had been outscored 68-20 during the skid.

Tyler Naquin doubled on the second pitch from Adam Wainwright (2-2), who walked Tommy Pham and Joey Votto with one out. Moran hit a sacrifice fly and Nick Senzel followed with an RBI single.

The Reds' 2-0 lead after the first inning was their first after a full inning since the 6-3 win at Atlanta on April 10.

Alejo Lopez singled leading off the second and scored on Naquin's RBI grounder for a 3-0 lead.

Lodolo (1-2), a 24-year-old left-hander selected seventh overall in the 2019 amateur draft, made his third big league start. Facing an exclusively right-handed lineup, he allowed three hits, struck out seven and walked none in 5 1/3 shutout innings before Paul Goldschmidt and Tyler O'Neill hit consecutive doubles in the sixth. Lodolo retired Nolan Arenado on a flyout, and Tony Santillan got Albert Pujols to pop out.

Lodolo has 15 strikeouts in a combined 10 2/3 innings over his last two starts.

Arenado went 0 for 4, ending his hitting streak at Great American Ball Park at 18 games, a stadium record.

The Reds avoided their longest losing streak since dropping 13 straight in 2015.

Pham scored two runs and had two hits, ending an 0-for-10 slide.

Wainwright (2-2) allowed four runs, eight hits and three walks in five-plus innings, and the Cardinals finished a 6-4 trip. Moran chased Wainwright with an RBI single in the sixth.

Miles Mikolas (1-0, 1.76) is the scheduled starter for Monday's opener of a three-game home series against the Mets.