Kyle Farmer homered twice, had four hits and tied his career-high with five RBIs in a 20-5 rout of the Chicago Cubs on Thursday.

Nick Senzel also had four hits, and Brandon Drury, Tommy Pham and Albert Almora Jr. had three apiece. Drury Pham, Almora and Matt Reynolds each had three RBIs.

The Reds entered with a .217 batting average, 28th among the 30 teams, and finished with 20 hits in all.

Cincinnati trailed 3-0 before scoring twice in the second and bursting ahead with eight runs in the third.

The Reds scored the most runs since a 22-3 win at Philadelphia on Sept. 4, 1999, while Chicago gave up its most since a 21-8 defeat at the Phillies on July 3, 1999.

Cubs shortstop Andrelton Simmons made his big league pitching debut, allowing five runs in the eighth.

Hunter Greene (2-6) won for the first time since his major league debut on April 10 despite giving up five runs, seven hits and two walks in five innings. He had been 0-6 with a 5.50 ERA in his previous seven starts.

Willson Contreras and Ian Happ hit back-to-back homers in the fifth. Nico Hoerner also homered for the Cubs.

Cubs starter Justin Steele (1-5) gave up seven runs, seven hits and two walks in two-plus innings.

The game was delayed by rain for 59 minutes at the end of the fifth.

The Cubs open a two-game series at the Chicago White Sox following an off day Friday.