Manny Machado lined a single for his 1,500th hit and hit a two-run homer in a four-RBI night to help the San Diego Padres beat the reeling Chicago Cubs 19-5 on Wednesday night.

Machado was one of five Padres with three hits as San Diego routed the Cubs for the second straight hot night at Wrigley Field. Jorge Alfaro added a two-run homer and three RBIs as San Diego improved to 40-24 in winning its third straight and seventh in nine.

Jake Cronenworth and Jurickson Profar each doubled twice and had three hits for the Padres, who remained percentage points behind the Dodgers. Luke Voit hit a solo homer off Frank Schwindel, mopping up in the ninth, for his third hit.

Rookie Christopher Morel had a solo shot and three RBIs for the Cubs, losers of nine straight. San Diego has outscored Chicago 35-11 in the first three of a four-game series.

Both starters, Chicago's Caleb Kilian and San Diego' Ryan Weathers, were recalled from the minors to fill gaps in their team's rotations - and struggled with control.

The Cubs pounced on Weathers' wildness in the second. He walked two with the bases loaded to force in runs, and Morel followed with a single that put Chicago ahead 4-2.

Morel homered in the sixth for the Cubs, and the Padres blew it open with five in the seventh.

To make room for Kilian on the roster, the Chicago placed INF Nick Madrigal on the 10-day IL with a left groin strain, retroactive to June 12. Madrigal last played on Friday at New York against the Yankees. 

Manager David Ross said OF Seiya Suzuki (left ring finger sprain) is throwing and has resumed some baseball activities, but isn't hitting yet.

Joe Musgrove (7-0, 1.50) faces Cubs RHP Matt Swarmer (1-1, 4.24) in the series finale on Thursday afternoon. Musgrove will pitch on five days' rest, and the Padres' 6-foot-5 ace hasn't allowed a run in two previous starts with five days' rest this season.