Ryan McMahon hit a 495-foot homer for the longest drive by a Colorado player at Coors Field, Randal Grichuk went 5 for 5 and the Rockies routed St. Louis 16-5 Tuesday night, ending the Cardinals' seven-game winning streak. 

Cardinals starter Miles Mikolas, an All-Star this season, was tagged for 10 runs and 14 hits in just 2 2/3 innings.

C.J. Cron homered and doubled to drive in five runs and Grichuk also connected as Colorado piled up 22 hits. 

Grichuk set a career high for hits and also drove in three runs and scored three. Brendan Rodgers matched a career high with four hits, Jose Iglesias added an RBI single among his three hits and Elias Diaz doubled twice and drove in a pair of runs.

The Rockies staked Ryan Feltner (2-3) to a 12-0 lead before St. Louis got on the board with a two-run homer by Paul DeJong in the fifth.

Nolan Arenado, who spent his first eight seasons in Colorado before being traded to St. Louis ahead of the 2021 season, had an RBI double in a three-run sixth. Andrew Knizner delivered a two-run single.

Most of the offensive damage by the Rockies came at the expense of Mikolas, who struggled to find a rhythm in hitter-friendly Coors Field.

Mikolas (8-9) gave up Cron's three-run drive in the first, his 23rd homer of the season. Mikolas was relieved by Packy Naughton after giving up a two-out, two-run double to Cron in the third. Naughton walked McMahon before Grichuk connected for his 12th homer of the season. 

Jose Quintana (3-5, 2.39 ERA) is set to make his second start Wednesday night for St. Louis since his Aug. 1 acquisition from Pittsburgh. He'll be opposed by Colorado's LHP Kyle Freeland (7-7, 4.56 ERA).